Inhibition of the SARS-CoV-2 3CLpro main protease by plant polyphenols
et al., Food Chemistry, doi:10.1016/j.foodchem.2021.131594 (In Vitro)
In Silico and In Vitro study of plant polyphenols identifying quercetin, curcumin, ellagic acid, epigallocatechin gallate and resveratrol as SARS-CoV-2 3CLpro inhibitors with IC50 between 11.8µM and 23.4µM. Real-time binding was analyzed with surface plasmon resonance spectroscopy.
Bahun et al., 11/14/2021, peer-reviewed, 10 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
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