Bhardwaja, 76 patient curcumin early treatment RCT: 89% improved recovery [p=0.05] and 24% improved viral clearance [p=0.47] https://c19p.org/bhardwajat
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An integrative approach to clinical recovery for COVID-19 patients using an Ayurvedic formulation: A multicentric double-blind randomized control trial.
et al., Research Square, doi:10.21203/rs.3.rs-1165680/v1 (Preprint)
Small RCT with 39 patients treated with NOQ19 and 37 placebo patients, showing improved recovery, without statistical significance. NOQ19 has multiple ingredients including curcumin and antiandrogen glycyrrhiza glabra. CTRI/2021/05/033790.
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risk of no hospital discharge, 36.8% lower, RR 0.63, p = 0.67, treatment 2 of 39 (5.1%), control 3 of 37 (8.1%), NNT 34, day 7.
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risk of no recovery, 89.1% lower, RR 0.11, p = 0.05, treatment 0 of 39 (0.0%), control 4 of 37 (10.8%), NNT 9.2, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), oxygen supplementation, day 5.
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risk of no recovery, 80.4% lower, RR 0.20, p = 0.23, treatment 0 of 39 (0.0%), control 2 of 37 (5.4%), NNT 18, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 7, dsypnea.
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risk of no recovery, 2.8% higher, RR 1.03, p = 1.00, treatment 13 of 39 (33.3%), control 12 of 37 (32.4%), day 7, fever.
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risk of no viral clearance, 24.1% lower, RR 0.76, p = 0.47, treatment 12 of 39 (30.8%), control 15 of 37 (40.5%), NNT 10, day 7.
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risk of no viral clearance, 5.1% lower, RR 0.95, p = 1.00, treatment 19 of 39 (48.7%), control 19 of 37 (51.4%), NNT 38, day 5.
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risk of no viral clearance, 12.4% lower, RR 0.88, p = 0.47, treatment 24 of 39 (61.5%), control 26 of 37 (70.3%), NNT 11, day 3.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
This study is excluded in meta
analysis:
combined treatments may contribute more to the effect seen.
Bhardwaja et al., 12/27/2021, Double Blind Randomized Controlled Trial, India, South Asia, preprint, 26 authors, this trial uses multiple treatments in the treatment arm (combined with 18 other ingredients) - results of individual treatments may vary.
bhardwaja
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