Hartono: The Effect of Curcumin and Virgin Coconut Oil Towards Cytokines Levels in COVID-19 Patients at Universitas Sebelas Maret Hospital, Surakarta, Indonesia

Hartono, 60 patient curcumin late treatment RCT: 53% improved viral clearance [p<0.0001] https://c19p.org/hartono

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The Effect of Curcumin and Virgin Coconut Oil Towards Cytokines Levels in COVID-19 Patients at Universitas Sebelas Maret Hospital, Surakarta, Indonesia

Hartono et al., Pharmacognosy Journal, doi:10.5530/pj.2022.14.27

22 Feb 2022 Source PDF Share Tweet

RCT with 30 patients treated with curcumin and virgin coconut oil (VCO), and 30 SOC patients in Indonesia, showing faster viral clearance with treatment. Treatment also reduced IL-1β, IL-2, IL-6, IL-18, and IFN-β levels. VCO improves the bioavailability of curcumin. There were large unadjusted differences in baseline severity and age, for example 20% vs. 47% of patients >50. VCO 30ml and curcumin 1g tid for 21 days. 066/UN27.06.6.1/KEPK/EC/2020.

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risk of no viral clearance, 53.3% lower, RR 0.47, p < 0.001, treatment 14 of 30 (46.7%), control 30 of 30 (100.0%), NNT 1.9, day 10.

risk of no viral clearance, 75.0% lower, RR 0.25, p = 0.002, treatment 4 of 30 (13.3%), control 16 of 30 (53.3%), NNT 2.5, day 14.

risk of no viral clearance, 66.7% lower, RR 0.33, p = 1.00, treatment 0 of 30 (0.0%), control 1 of 30 (3.3%), NNT 30, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 21.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

This study is excluded in the after exclusion results of meta analysis: randomization resulted in significant baseline differences that were not adjusted for.

Hartono et al., 22 Feb 2022, Randomized Controlled Trial, Indonesia, peer-reviewed, 13 authors, this trial uses multiple treatments in the treatment arm (combined with virgin coconut oil) - results of individual treatments may vary.

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Late treatment
is less effective

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