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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Improvement in SpO2 -46% Improvement Relative Risk c19curcumin.com/hassaniazad.html Favors curcumin Favors control
19 September 2021 - Late treatment study
A triple-blind, placebo-controlled, randomized clinical trial to evaluate the effect of curcumin-containing nanomicelles on cellular immune responses subtypes and clinical outcome in COVID-19 patients
Hassaniazad et al., Phytotherapy Research, doi:10.1002/ptr.7294 (Peer Reviewed)
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Small RCT with 40 low risk patients in Iran, 20 treated with nano-curcumin, showing no significant difference in outcomes with treatment. Authors note that treatment can improve peripheral blood inflammatory indices and modulate immune response by decreasing Th1 and Th17 responses, increasing T regulatory responses, further reducing IL-17 and IFN-γ, and increasing suppressive cytokines TGF-β and IL-4.
relative improvement in SpO2, 45.7% worse, RR 1.46, p = 0.90, treatment 20, control 20.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Hassaniazad et al., 9/19/2021, Double Blind Randomized Controlled Trial, placebo-controlled, Iran, Middle East, peer-reviewed, 12 authors.
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