Sankhe, 120 patient curcumin late treatment RCT: 86% lower mortality [p=0.24], 86% lower ventilation [p=0.24], 10% shorter hospitalization [p=0.4], and 32% faster recovery [p=0.001] https://c19p.org/sankhe2
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A Randomized, Controlled, Blinded, Parallel Group, Clinical Trial to study the role of Ayurcov (AyurCoro3), one day regimen as an adjuvant therapy for COVID-19 disease management, at dedicated Covid Hospital (DCH) in India
et al., Complementary Therapies in Medicine, doi:10.1016/j.ctim.2022.102824
RCT with 60 hospitalized patients treated with Ayurcov and 60 control patients in India, showing improved viral clearance and faster symptom resolution in the mild/moderate group, but no significant differences in the severe group. Ayurcov contains curcuma longa, go ark, sphatika (alum), sita (rock candy), godugdham (bos indicus) milk, and goghritam (bos indicus ghee).
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risk of death, 85.7% lower, RR 0.14, p = 0.24, treatment 0 of 60 (0.0%), control 3 of 60 (5.0%), NNT 20, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
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risk of mechanical ventilation, 85.7% lower, RR 0.14, p = 0.24, treatment 0 of 60 (0.0%), control 3 of 60 (5.0%), NNT 20, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
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risk of ICU admission, 66.7% lower, RR 0.33, p = 0.62, treatment 1 of 60 (1.7%), control 3 of 60 (5.0%), NNT 30.
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hospitalization time, 10.0% lower, relative time 0.90, p = 0.40, treatment 45, control 45, moderate group.
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hospitalization time, 16.7% lower, relative time 0.83, p = 0.20, treatment 15, control 15, severe group.
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recovery time, 31.9% lower, relative time 0.68, p < 0.001, treatment 45, control 45, moderate group, fever.
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recovery time, 36.1% lower, relative time 0.64, p < 0.001, treatment 45, control 45, moderate group, dyspnea.
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recovery time, 4.3% lower, relative time 0.96, p = 0.74, treatment 15, control 15, severe group, fever.
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recovery time, 4.8% higher, relative time 1.05, p = 0.10, treatment 15, control 15, severe group, dyspnea.
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relative Ct increase, 44.4% better, RR 0.56, p = 0.003, treatment mean 9.98 (±6.39) n=44, control mean 5.55 (±6.91) n=43, moderate group.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Sankhe et al., 25 Mar 2022, Single Blind Randomized Controlled Trial, India, peer-reviewed, 10 authors, this trial uses multiple treatments in the treatment arm (combined with gomutra, potassium alum, khadisakhar, bos indicus milk, ghee) - results of individual treatments may vary.
Contact:
apsankhe@bhaktivedantahospital.com (corresponding author), nirmal.rns@gmail.com, drvijaykumar@bhaktivedantahospital.com, drsonal.memane@bhaktivedantahospital.com, ganesh@cse.iitb.ac.in, tkundu@phy.iitb.ac.in, mayur.bagul@bhaktivedantahospital.com, ashutoshk@iitb.ac.in, vbansal108@gmail.com, rashmistats@gmail.com.
Late treatment
is less effective
is less effective
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