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0 0.5 1 1.5 2+ Mortality 86% Improvement Relative Risk Ventilation 86% ICU admission 67% Hospitalization time 10% Hospitalization time (b) 17% Recovery time, fever 32% Recovery time, dyspnea 36% Recovery time, fever (b) 4% Recovery time, dyspnea (b) -5% Ct increase 44% c19curcumin.com Sankhe et al. Curcumin for COVID-19 RCT LATE TREATMENT Favors curcumin Favors control
Sankhe, 120 patient curcumin late treatment RCT: 86% lower mortality [p=0.24], 86% lower ventilation [p=0.24], 10% shorter hospitalization [p=0.4], and 32% faster recovery [p=0.001] https://c19p.org/sankhe2
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A Randomized, Controlled, Blinded, Parallel Group, Clinical Trial to study the role of Ayurcov (AyurCoro3), one day regimen as an adjuvant therapy for COVID-19 disease management, at dedicated Covid Hospital (DCH) in India
Sankhe et al., Complementary Therapies in Medicine, doi:10.1016/j.ctim.2022.102824
25 Mar 2022    Source   PDF   Share   Tweet
RCT with 60 hospitalized patients treated with Ayurcov and 60 control patients in India, showing improved viral clearance and faster symptom resolution in the mild/moderate group, but no significant differences in the severe group. Ayurcov contains curcuma longa, go ark, sphatika (alum), sita (rock candy), godugdham (bos indicus) milk, and goghritam (bos indicus ghee).
risk of death, 85.7% lower, RR 0.14, p = 0.24, treatment 0 of 60 (0.0%), control 3 of 60 (5.0%), NNT 20, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of mechanical ventilation, 85.7% lower, RR 0.14, p = 0.24, treatment 0 of 60 (0.0%), control 3 of 60 (5.0%), NNT 20, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of ICU admission, 66.7% lower, RR 0.33, p = 0.62, treatment 1 of 60 (1.7%), control 3 of 60 (5.0%), NNT 30.
hospitalization time, 10.0% lower, relative time 0.90, p = 0.40, treatment 45, control 45, moderate group.
hospitalization time, 16.7% lower, relative time 0.83, p = 0.20, treatment 15, control 15, severe group.
recovery time, 31.9% lower, relative time 0.68, p < 0.001, treatment 45, control 45, moderate group, fever.
recovery time, 36.1% lower, relative time 0.64, p < 0.001, treatment 45, control 45, moderate group, dyspnea.
recovery time, 4.3% lower, relative time 0.96, p = 0.74, treatment 15, control 15, severe group, fever.
recovery time, 4.8% higher, relative time 1.05, p = 0.10, treatment 15, control 15, severe group, dyspnea.
relative Ct increase, 44.4% better, RR 0.56, p = 0.003, treatment mean 9.98 (±6.39) n=44, control mean 5.55 (±6.91) n=43, moderate group.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sankhe et al., 3/25/2022, Single Blind Randomized Controlled Trial, India, South Asia, peer-reviewed, 10 authors, this trial uses multiple treatments in the treatment arm (combined with gomutra, potassium alum, khadisakhar, bos indicus milk, ghee) - results of individual treatments may vary.
Contact: apsankhe@bhaktivedantahospital.com (corresponding author), nirmal.rns@gmail.com, drvijaykumar@bhaktivedantahospital.com, drsonal.memane@bhaktivedantahospital.com, ganesh@cse.iitb.ac.in, tkundu@phy.iitb.ac.in, mayur.bagul@bhaktivedantahospital.com, ashutoshk@iitb.ac.in, vbansal108@gmail.com, rashmistats@gmail.com.
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is less effective
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