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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 83% Improvement Relative Risk Mortality (b) 67% Mortality (c) 80% c19curcumin.com/tahmasebi.html Favors curcumin Favors control
28 March 2021 - Late treatment study
Nanocurcumin improves Treg cell responses in patients with mild and severe SARS-CoV2
Tahmasebi et al., Life Sciences, doi:10.1016/j.lfs.2021.119437 (Peer Reviewed)
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RCT 40 hospitalized, 40 ICU, and 40 control patients in Iran, showing lower mortality and improved regulatory T cell responses with nanocurcumin treatment (SinaCurcumin).
risk of death, 83.3% lower, RR 0.17, p = 0.11, treatment 1 of 40 (2.5%), control 6 of 40 (15.0%), NNT 8.0.
risk of death, 66.7% lower, RR 0.33, p = 1.00, treatment 0 of 20 (0.0%), control 1 of 20 (5.0%), NNT 20, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), non-ICU patients.
risk of death, 80.0% lower, RR 0.20, p = 0.18, treatment 1 of 20 (5.0%), control 5 of 20 (25.0%), NNT 5.0, ICU patients.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Tahmasebi et al., 3/28/2021, Double Blind Randomized Controlled Trial, Iran, Middle East, peer-reviewed, 14 authors.
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