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Bromhexine Nigella Sativa
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Curcumin study #5 of 13   All Outcomes
3/28 Late treatment study
Tahmasebi et al., Life Sciences, doi:10.1016/j.lfs.2021.119437 (Peer Reviewed)
Nanocurcumin improves Treg cell responses in patients with mild and severe SARS-CoV2
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RCT 40 hospitalized, 40 ICU, and 40 control patients in Iran, showing lower mortality and improved regulatory T cell responses with nanocurcumin treatment (SinaCurcumin).
Tahmasebi et al., 3/28/2021, Double Blind Randomized Controlled Trial, Iran, Middle East, peer-reviewed, 14 authors.
risk of death, 83.3% lower, RR 0.17, p = 0.11, treatment 1 of 40 (2.5%), control 6 of 40 (15.0%).
risk of death, 66.7% lower, RR 0.33, p = 1.00, treatment 0 of 20 (0.0%), control 1 of 20 (5.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), non-ICU patients.
risk of death, 80.0% lower, RR 0.20, p = 0.18, treatment 1 of 20 (5.0%), control 5 of 20 (25.0%), ICU patients.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
All 13 studies   All Outcomes
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