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0 0.5 1 1.5 2+ Mortality 71% Improvement Relative Risk Recovery, dyspnea 86% Recovery, fever >39.0 90% Recovery, bilateral chest.. 38% Recovery, cough 59% Recovery, headache 82% c19curcumin.com Abbaspour-Aghdam et al. IRCT20200324046851N1 Curcumin RCT LATE Favors curcumin Favors control
Abbaspour-Aghdam, 60 patient curcumin late treatment RCT: 71% lower mortality [p=0.15] and 86% improved recovery [p=0.04] https://c19p.org/abbaspouraghdam
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Immunomodulatory role of Nanocurcumin in COVID-19 patients with dropped natural killer cells frequency and function
Abbaspour-Aghdam et al., European Journal of Pharmacology, doi:10.1016/j.ejphar.2022.175267, IRCT20200324046851N1
17 Sep 2022    Source   PDF   Share   Tweet
RCT with 30 nanocurcumin and 30 control patients in Iran, showing lower mortality and improved recovery, without statistical significance, and improved NK cell function. 160mg nanocurcumin for 21 days.
risk of death, 71.4% lower, RR 0.29, p = 0.15, treatment 2 of 30 (6.7%), control 7 of 30 (23.3%), NNT 6.0.
risk of no recovery, 86.3% lower, RR 0.14, p = 0.04, treatment 1 of 28 (3.6%), control 6 of 23 (26.1%), NNT 4.4, dyspnea.
risk of no recovery, 89.9% lower, RR 0.10, p = 0.04, treatment 0 of 28 (0.0%), control 4 of 23 (17.4%), NNT 5.8, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), fever >39.0.
risk of no recovery, 38.4% lower, RR 0.62, p = 0.17, treatment 9 of 28 (32.1%), control 12 of 23 (52.2%), NNT 5.0, bilateral chest radiograph involvement.
risk of no recovery, 58.9% lower, RR 0.41, p = 0.27, treatment 3 of 28 (10.7%), control 6 of 23 (26.1%), NNT 6.5, cough.
risk of no recovery, 81.6% lower, RR 0.18, p = 0.20, treatment 0 of 28 (0.0%), control 2 of 23 (8.7%), NNT 12, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), headache.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Abbaspour-Aghdam et al., 17 Sep 2022, Randomized Controlled Trial, placebo-controlled, Iran, peer-reviewed, 16 authors, trial IRCT20200324046851N1.
Contact: ahmadi.m@tbzmed.ac.ir.
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