• Statistically significant improvements are seen for mortality, hospitalization, recovery, and viral clearance. 11 studies from 10 independent teams in 6 different countries show statistically significant improvements in isolation (7 for the most serious outcome).
• Meta analysis using the most serious outcome reported shows 39% [31‑46%] improvement. Results are similar for Randomized Controlled Trials, similar after exclusions, and similar for peer-reviewed studies.
• Results are robust — in exclusion sensitivity analysis 17 of 21 studies must be excluded to avoid finding statistically significant efficacy in pooled analysis.
• Studies typically use advanced formulations for greatly improved bioavailability.
• No treatment, vaccine, or intervention is 100% effective and available. All practical, effective, and safe means should be used based on risk/benefit analysis. Multiple treatments are typically used in combination, and other treatments may be more effective. Only 24% of curcumin studies show zero events with treatment. The quality of non-prescription supplements can vary widely [Crawford, Crighton].
• All data to reproduce this paper and sources are in the appendix. Other meta analyses for curcumin can be found in [Kow, Vahedian-Azimi], showing significant improvements for mortality, hospitalization, and symptoms.
Covid Analysis et al., 30 Sep 2022, preprint, 1 author.